Pancreatic Cancer Comprehensive Panel

Sample Required: Buccal Swab (included in kit)

Number of Genes: 24

Genes included: APC, ATM, BMPR1A, BRCA1, BRCA2, BUB1B, CDK4, CDKN2A, EPCAM, FANCA, FANCC, MEN1, MLH1, MSH2, MSH6, NF1, PALB2, PMS2, SMAD4, STK11, TP53, TSC1, TSC2, VHL

This is for patients with an actual or potential cancer diagnosis, especially for those with a personal or family history suggestive of a hereditary pancreatic cancer syndrome. Indications of a likely hereditary pancreatic cancer include early onset of cancer (before 50), more than one primary cancer in a single person, and multiple affected people within a family.

This test is appropriate for patients with both isolated pancreatic cancer, as well as those that may have other clinical findings suggestive of a genetic syndrome. Other cancers that can sometimes co-occur in families with a syndrome that increases the risk for pancreatic cancer could include melanoma and breast, ovarian, colorectal, gastric, or thyroid cancer, amongst others.

Genetic testing for hereditary cancer can:

• Establish or confirm a diagnosis

• Identify risk for other cancers and health conditions

• Assist in modifying lifestyle changes

• Result in more personalised treatment, which may include increased screening and pharmacological treatments.